between CR1 and CR3 in the binding of complementopsonized
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An adenovirus E1A transcriptional repressor domain functions as an activator when tethered to a promoter.
The adenovirus E1A protein contains three well conserved regions, designated conserved region (CR) 1, 2 and 3, which are important for the multiple activities ascribed to E1A. The CR3 domain constitutes a prototypic transcription activator, consisting of a promoter targeting region and a transactivating region. Here we demonstrate the existence of a second transactivating region located within ...
متن کاملJFRA-103 from the American Cancer Society, and a grant-in-aid from the American Heart Association with funds contributed in part by the Florida Affiliate. P. Detmers is an Arthritis
Receptors for C3 bind ligand and generate intracellular signals that lead to the engulfment of C3-coated particles. Recent experiments suggest that both the binding and the subsequent signal transduction activities of C3 receptors can be regulated. Cultured human monocytes (MO) 1 express receptors for C3b (CR1) and C3bi (CR3) that bind ligand-coated particles but do not signal the cell to initi...
متن کاملPhagocytosis of leprosy bacilli is mediated by complement receptors CR1 and CR3 on human monocytes and complement component C3 in serum.
Mycobacterium leprae, an obligate intracellular pathogen, invades and multiplies within host mononuclear phagocytes. To understand M. leprae invasion better, we have investigated the role of phagocyte receptors and bacterium-bound ligands in phagocytosis of M. leprae by human monocytes. Complement receptors CR1 and CR3 mediate adherence and phagocytosis of M. leprae in nonimmune serum. Two MAbs...
متن کاملPhagocytosis of Legionella pneumophila is mediated by human monocyte complement receptors
We have examined receptors mediating phagocytosis of the intracellular bacterial pathogen, Legionella pneumophila. Three mAbs against the type 3 complement receptor (CR3), which recognizes C3bi, inhibit adherence of L. pneumophila to monocytes by 64 +/- 8% to 74 +/- 11%. An mAb against the type 1 complement receptor (CR1), which recognizes C3b, inhibits adherence by 68 +/- 1%. mAbs against othe...
متن کاملTumor necrosis factor is the major monocyte product that increases complement receptor expression on mature human neutrophils.
Interleukin-1 (IL-1) and other monocyte products have several important effects on the systemic response to infection in addition to their roles in lymphocyte stimulation. The present studies were carried out to determine whether products of stimulated monocytes activated circulating neutrophils (PMN) to increase expression of receptors for C3b (CR1) and C3bi (CR3), which are necessary for opti...
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تاریخ انتشار 2006